On March 18th, the 3rd Yangtze River Delta Translational Medicine (Medical Device Direction) Innovation and Entrepreneurship Competition was held in Gaochun, Nanjing, under the guidance of Jiangsu Development and Reform Commission, Jiangsu Department of Industry and Information Technology, and Jiangsu Pharmaceutical Administration, and jointly organized by Jiangsu Society of Research Hospitals and members of Yangtze River Delta Healthcare Industry Alliance, and the project of "NanoKnife Tumor Ablation System (Irreversible)" of SUNEON successfully passed the preliminary and final rounds and entered the grand final, and finally won the second prize. The project "NanoKnife Tumor Ablation System (Irreversible Electroporation)" of Xian'o successfully entered the Grand Final through the preliminary and final rounds, and finally won the Second Prize of the Grand Final.

Academicians of Chinese Academy of Engineering Wang Xuehao and Ying Hanjie, Deputy Director of Jiangsu Provincial Department of Industry and Information Technology Ji Yu, Second Inspector of Provincial Development and Reform Commission Lu Health, Deputy Director of Provincial Pharmaceutical Administration Chen Heping, and leaders of Gaochun District Zhao Huoping, Huang Yiwu, Wang Fei, Liu Min, Kong Lingjie, and Yang Shiping were present at the event. The Yangtze River Delta Translational Medicine Competition, which continues to receive high attention from the industry, has become a well-known brand event. Competition to the Yangtze River Delta region for the scope of the project collection, this year since the preliminary round, received from Shanghai, Jiangsu, Zhejiang, Anhui provinces and cities, hospitals, universities, research units, enterprises recommended more than 700 pieces of submissions, after several rounds of competition, from the three provinces and cities of colleges and universities, hospitals, medical device companies 18 projects into the finals.

The finals of the Medical Translation Competition was divided into project roadshow and defense session, Mr. Gao Wenhua, the founder of Xian'eu Company, fully explained the position of "NanoKnife Tumor Ablation System" in the medical field and its importance in the field of cancer cell ablation, the nanoKnife at present, the domestic mainly relies on imports, the single set of bidding price of 7,800,000 yuan, it is urgent to speed up the independent innovation of the NanoKnife Tumor Ablation Technology, which is of great strategic significance for the development of China's high-end medical devices.

NanoKnife" - Steep Pulse Irreversible Electroporation Technology, referred to as "NanoKnife", its therapeutic principle is to release high-voltage pulse voltage (up to 3,000V or more) through ablation against tumor cells, and the high-intensity electric pulse can cause nano-sized irreversible electroporation of the tumor cell membrane, which will destroy the cellular balance, thus leading to cell apoptosis. The high intensity electric pulse can cause irreversible electroporation of the tumor cell membrane at the nanometer scale, destroying the intracellular balance and leading to apoptosis. After the apoptosis of tumor cells, the phagocytes in the body will devour the cell fragments, and the treatment area will be gradually replaced by normal tissues, so NanoKnife is also known as irreversible electroporation in medical science. Compared to other physical ablation methods (radiofrequency, microwave and argon helium knife), the destruction of tissues is not selective, and if the tumor is located in the vicinity of important structures such as blood vessels and nerves, it may damage the said structures. Nanoknife uses electroporation technology to ablate tumors, and the connective tissue in the wall structure of the adjacent vascular system is impenetrable, so there is little damage to the blood vessels, nerves, bile ducts, intestinal tubes, and other structures, which makes up for the shortcomings of conventional physical ablation, significantly expands the scope of tumor treatment, and improves the rate of treatment of tumors. NanoKnife is suitable for thyroid, liver, lung, kidney, pancreas, prostate, breast and other solid tumors, especially for tumors close to the hepatoportal area, gallbladder bile ducts, pancreas, and ureter with unique advantages.

About Nanjing XIANOU (ATPIO) Instrument Manufacture Co.,Ltd.

Founded in 2010
Third Prize of Nanjing Science and Technology Progress in 2013
2014 Recognized as a national high-tech enterprise
2015 Nanjing Excellent Invention Patent Award
Second Prize of Jiangsu Scientific and Technological Progress in 2015
2015 17th China Patent Excellence Award
2015 Nanjing Patent Excellence Award
2015 Second Prize of Scientific and Technological Progress of Ministry of Education
2015 Nanjing Science and Technology Progress Third Prize
Undertaking Nanjing Science and Technology Development Program (Patent Secondary Development) in 2017
Second Prize of National Commercial Progress in 2017
Third Prize of Jiangsu Provincial Scientific and Technological Progress in 2018
2019 Second Prize of Scientific and Technological Progress of China Surface Engineering Association
2019 Company founder Gao Wenhua recognized as Nanjing Science and Technology Entrepreneur by Jiangsu Provincial Party Committee Organization Department
2020 First Prize of Technical Invention by Ministry of Education
The 23rd China Patent Excellence Award in 2022